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We further show that overexpression of enzymes or supplementation of key metabolites in the transsulfuration pathway of SAA metabolism significantly restores the sensitivity of HNF4-depleted liver cancer cells to methionine/cystine restriction or sorafenib treatment and inhibits cell migration (Fig

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Short-term studies on HBV-inducible cell line HepAD38 also confirmed that HBV replication stimulates oxidative stress, as revealed by higher MDA levels after 24-h induction

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