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Take a digestive organ cell, for example, we'll assume that it requires high amounts of NADPH for fatty acid synthesis

The accumulation of visceral fat, a typical symptom of obesity, leads to the production of adipokines such as leptin (8), lipocalin (9), C1q tumor necrosis factor-related protein 9 (10), chemerin (11), and retinol-binding protein 4 (12), which are involved in a variety of metabolic processes such as glucose uptake, insulin signaling, and fatty acid oxidation, and are highly correlated with T2DM and cardiovascular and microvascular complications are highly relevant (13, 14)

By properly I mean TSH, Free T4, Free T3, thyroid antibodies, iron & ferritin, vitamin D, vitamin B12

By using lab tests and doctor checks together, we can make B12 treatment better for our patients