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Polymorphisms are also present in GSTs of the alpha class and omega class, with the isoenzymes GSTA1-1, GSTA2-2 and GSTO1-1 and GSTO2, respectively 32

The humanised anti-HGF antagonistic antibody ficlatuzumab did not yield clinical benefits as a monotherapy, but resulted in a 19% ORR in patients with HNSCC when combined with cetuximab [399]

This may be related to its potential to decrease the burden of senescent cells