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GSH is essential for the detoxification of hydrogen peroxide (H 2 O 2 ) and therefore, cellular defense against the oxidizing effects of H 2 O 2 is absolutely dependent upon the generation of NADPH

Medicine (Baltimore) 102(40):E35306

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doi: 10.3389/fendo.2025.1684744 Received 13 August 2025 Revised 01 October 2025 Accepted 05 November 2025 Published 21 November 2025 Volume 16 - 2025 Edited by Eleonore Frhlich, Medical University of Graz, Austria Reviewed by Hussam Wahab Al-Humadi, University of Babylon, Iraq Yuting Cui, Affiliated Hospital of Nanjing University of Chinese Medicine, China Updates Copyright 2025 Song, Li, Shi, Liu, Qu and Wang