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Notably, for some forms of plasticity in interneurons, the relation between the magnitude of [Ca 2+ ] i rise and induction of LTP or LTD could be different from that in pyramidal neurons, e.g., lacking the LTD window altogether (Le Roux et al., 2013) or even the inverse (whereby lower influx induces LTP and LTD occurring after higher rises)

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An associative induction protocol (burst frequency stimulation of mossy fibers paired with postsynaptic spikes) induced LTP in these cells while a nonassociative protocol (same burst frequency stimulation but paired with hyperpolarization preventing spikes) induced LTD (Alle et al., 2001