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Acta Pharmacol Sin 43:251259

MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Limited human safety data Animal toxicology shows wide therapeutic window Injection-site reactions reported anecdotally Known interactions Anticoagulants (theoretical, due to angiogenic activity unstudied) Contraindications Active malignancy (theoretical, due to angiogenic mechanism) Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Placed on FDA Category 2 of the 503A bulks list (September 2023 update), barring compounding pharmacies from preparing it under section 503A

Glutathione, a tripeptide naturally found in the body, consists of cysteine, glutamic acid, and glycine

Left panel (Mechanism of Action & Pharmacodynamics) : Imipramine inhibits the serotonin transporter (SERT) and norepinephrine transporter (NET), resulting in increased synaptic concentrations of serotonin and norepinephrine (dual monoamine reuptake inhibition)