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To assess the relationship between female sex and perfusion metrics, we employed generalized linear mixed model analysis in univariate models and after adjusting for age, sex, time since last seen well, ASPECTS, periventricular Fazekas scale, and brain volume

Importantly, REDEFINE 1 also showed that a significant proportion of participants achieved 25% body weight reduction a threshold that, in clinical terms, represents the kind of weight loss previously achievable only through bariatric surgery

OCEBM levels of evidence system

The logic is sound: you get concentrated local delivery to the target tissue plus systemic support for the repair machinery behind it