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advanced schedules raise frequency rather than single-dose size

However, intranasal administration is also considered an efficient route for systemic effects due to the dense vasculature of the nasal mucosa

REDEFINE is an ongoing phase 3 trial acting as market evaluation for both CagriSema and cagrilintide, with 60% randomised to CagriSema, 10% cagrilintide, 10% semaglutide, and 20% placebo, where minimum age at inclusion was 55 years with no upper limit [117]

Conclusion Intranasal vitamin B12 administration is an effective and appropriate method for restoring and maintaining adequate vitamin B12 levels in elderly patients with a deficiency