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What we do know: In one Dutch study when people with IBS or IBD and normal B12 levels were given a daily B12 supplement, they didnt report any significant improvements in fatigue, depression, or quality of life

The sub-30-minute plasma half-life is the pharmacokinetic basis for twice-daily dosing, though no human study has confirmed this produces better outcomes

While some patients receive these shots at a clinic, many are advised by their healthcare providers to self-inject at home for convenience and consistency

Marqueling and Wang dont know whether Liam, now 5, got the actual drug or the placebo during the clinical trial