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In: Farage MA, Miller KW, Maibach HI, editors

10.1074/jbc.272.41.25417 J

When a too high concentration of antioxidants (e.g., ascorbate) is used, a switch from antioxidant to prooxidant behavior may occur, especially under certain conditions (e.g., highly oxygenated tissues such as lungs or the presence of redox-active metals such as Cu or Fe)