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There are many practical difficulties associated with subjects smoking in the modern neuroscientific laboratory environment, however electronic cigarettes obviate many of these issues, and provide a close simulation of smoking tobacco cigarettes

A meta-analysis of 6 case-control studies (4209 malformed cases and 10,646 controls) published between 2000 and 2010 revealed that maternal smoking during pregnancy significantly increased the risk of cleft lip with or without cleft palate (OR 1.48, 95% CI 1.361.61) [25]

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