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The significant cell damage and loss result in decreased dopamine concentration within the striatum and the dysfunction of the nigrostriatal pathway

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A specific role for IGF-1 receptor (IGF-1R) signaling in the mediation of mammalian longevity was first established in IGF-1R haploinsufficient mice, which lived 33% longer than controls, but unlike other models of reduced somatotropic signaling, this effect was female specific 6

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Schizophr Bull 38(3):42632 Nilsson LK et al (2005) Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia

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