When T2D-like disease model mice are fed a high-calorie diet, the accumulation of oxidative stress in adipose tissue and senescence-associated alterations, including increases in p53 levels, proinflammatory cytokine levels, and senescence-associated beta-galactosidase activity, are observed
The safety profile was consistent with GLP-1 receptor agonists, primarily featuring transient, mild-to-moderate gastrointestinal adverse events (e.g., nausea, 55%), with low discontinuation rates (6-8.4%)
[1,6] The activation of and increase in pro-inflammatory products in response to cellular damage from oxidative stress, coupled with a decreased abundance and activity of endogenous antioxidants, is thought to be one of the key players in the pathophysiology of psoriasis
One study reported an increase in the fecal levels of the beneficial microbe Bifidobacterium and a decrease in pathogenic Enterobacteriaceae in infants born to mothers who consumed 250 g of yogurt (6 days/week) during pregnancy (between 12 and 24 weeks of gestation), and up to 1 month postpartum (64)