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Here are some examples: Cocaine + alcohol can cause toxic effects on the heart

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In addition to increasing kidney stone risk, smoking cigarettes increases risk of many chronic diseases such as: (g) Cancer Heart Disease & Stroke Respiratory Diseases Diabetes Asthma Macular degeneration Rhematoid arthritis Bone health If you smoke cigarettes and have kidney stones, it is a good idea to stop smoking to both reduce risk of more kidney stones and other severe chronic diseases