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Deleterious off-target effects in women 10 years or more past menopause, such as ovarian, endometrial, and breast cancers, intravascular thrombosis, cardiovascular episodes, and stroke, and suppression of endogenous testosterone and libido and increased risk of prostate cancer in men, have precluded broad clinical applications (Stevenson and Thornton, 2007)

Fluoxetine: a case history of its discovery and preclinical development

Semaglutide withdrawal symptoms apply similarly to tirzepatide: increased appetite, potential weight regain, and sometimes temporary metabolic slowdown