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The major part of the flux is carried by the low affinity transporter, which has sigmoidal kinetics with a V max in the range 9001400 M/hr, a K m of approximately 3000 M, and a Hill coefficient of approximately 3 [3436]

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Specifically, it upregulates genes involved in collagen synthesis (Types I, III, and V), decorin production (which regulates collagen fibril assembly), integrin and glycosaminoglycan synthesis, DNA repair enzymes, antioxidant defense systems (superoxide dismutase, glutathione), and stem cell markers