The standard care for tendon, ligament, muscle, and bone injuries remains the foundation, and its a foundation built on decades of solid evidence: Conservative treatment : Rest, physical therapy, progressive loading, anti-inflammatory management, and activity modification remain first-line approaches for most musculoskeletal injuries
However, the expression of an additional cathelicidin antimicrobial peptide, or the overexpression of a cathelicidin gene protects transgenic mice against bacterial skin infections [178]
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The damage from freeze-thaw cycles comes from repeated freezing and thawing of the same solution, where ice crystals form, melt, reform, and melt again, each cycle physically stressing the peptide molecules