Taken together, glutamatergic abnormalities are a consistent feature of mid-life depression, with lower mGluR5 across cortical and hippocampal regions linked to symptom severity and cognitive deficits, and ketamine-induced glutamatergic modulation associated with clinical improvement
References: rxlist.com Cafcit (caffeine citrate) New York Times (Nov 15, 2012) Keywords Nicotine Trade Names: Nicotrol Inhaler Drug Class: Nicotinic Cholinomimetic Mechanism of Action: Binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia , in the adrenal medulla , at neuromuscular junctions , and in the brain Two types of central nervous system effects are believed to be the basis of nicotines positively reinforcing properties: A stimulating effect is exerted mainly in the cortex via the locus ceruleus A reward effect is exerted in the limbic system At low doses the stimulant effects predominate while at high doses the reward effects predominate The cardiovascular effects of nicotine include peripheral vasoconstriction, tachycardia, and elevated blood pressure Indications: Aid to smoking cessation for the relief of nicotine withdrawal symptoms Contraindications: Known hypersensitivity or allergy to nicotine or to menthol Side Effects: The toxic effects of acute nicotine poisoning can be divided into early & late phases (Schep et al, 2009
Beyond-use window: reconstituted solution has a limited stable life (commonly a few weeks refrigerated)
GHK-Cu copper peptide signals fibroblasts, hair follicle stem cells, and tissue repair pathways
