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For IGF-1 LR3, the limitation is different: the reproducible evidence is real but confined to cell culture and non-muscle animal models, so its muscle-hypertrophy reputation rests largely on inference from general IGF-1 biology rather than on direct, controlled muscle studies of the analog itself

We would like to thank Nozaki Tokushukai Hospital for financial support and Editage (www.editage.com) for English language editing

Mice were housed at 1824C at 4070% relative humidity, with a 12-h light/dark cycle

That said, many modern peptide protocols have shifted toward CJC-1295/Ipamorelin blends for potentially greater effect