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Extracellular mtDNA can act as a damage-associated molecular pattern (DAMP), triggering the activation of innate immune receptors such as toll-like receptors (TLRs) and inducing the production of type I interferons (IFNs) [131]

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Mol Immunol (2008) 45(9):26909.10.1016/j.molimm.2007.12.010 152 AmdekarSSinghVSinghRSharmaPKeshavPKumarA