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Recently, the hNGPp peptide that harbors a mutation reducing the pro-nociceptive activity of NGF, delivered intranasally in mice, activated the TrkA and downstream Erk1/2, Akt pathways leading to neuroprotective and anti-amyloidogenic actions ( Statements Data availability statement All datasets generated for this study are included in the manuscript and/or the supplementary files

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Moreover, these drugs are often associated with side effects such as gastrointestinal distress, dizziness, and nausea, further limiting their long-term clinical utility (AlzheimersAssociation, 2022)