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Additional risk factors include having your gut operated on, pancreatic insufficiency, small intestinal bacterial overgrowth (SIBO), parasite infections, and certain autoimmune disorders

Hence, it was postulated that the brain drives these psychiatric comorbidities seen in IBS patients, which leads to the conclusion that IBS is a primary brain disorder or somatic symptom disorder whereby the brain is involved in manifesting the gastrointestinal symptoms (Tanaka et al., 2011

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Potential muscle-related effects include: Improved body composition Reduced visceral fat Mild increases in lean mass In a randomized, placebo-controlled study in HIV-infected adults with abdominal fat accumulation, daily subcutaneous tesamorelin for six months significantly reduced visceral adipose tissue compared with placebo and also increased trunk and total lean body mass, indicating improved overall body composition beyond just weight changes