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In some embodiments, the otic pharmaceutical formulations or devices described herein are low viscosity formulations or devices at body temperature

Neutrophils that undergo ferroptosis may die and emit damage-associated molecular patterns (DAMPs), which intensifies the inflammatory response (68)

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This process occurs through the carnitine shuttle system, which includes key enzymes such as carnitine palmitoyltransferase I (CPT I) and carnitine palmitoyltransferase II (CPT II)