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As an important channel of essential oxygen and energy sources for the brain, cerebral microvessels are an important component of the bloodbrain barrier (BBB), and its disruption is an early pathophysiological mechanism in neurodegenerative diseases (20)

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Patients should stop tirzepatide and seek immediate medical care if they experience severe, persistent abdominal pain (which may indicate pancreatitis), symptoms of gallbladder disease (right upper quadrant pain, fever, jaundice), persistent vomiting leading to dehydration (which may cause acute kidney injury), or signs of severe allergic reaction

Recently, McDonough et al