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Chou CC, Lee KH, Lai IL, Wang D, Mo X, Kulp SK, Shapiro CL, Chen CS

Made in the liver and kidneys, L-carnitine is an amino acid

Primary research: Gut inflammation, skin barrier function, general anti-inflammatory Mechanism: Inhibits NF-B inflammatory signaling pathway activation Key advantage: Anti-inflammatory effects without immunosuppression a critical distinction from corticosteroids Regulatory status: Not FDA-approved

A further hypothesis is that ME/CFS could include misdirected immune responses to the initial infection, resulting in a chronic autoimmune disease with molecular mimicry (the hit and run hypothesis) (85)