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Limitations of the Study 1) The initial 3-day round of DMSA in Phase 1 was intended as a screening for Phase 2, but it was discovered that the initial round of DMSA had a large beneficial effect in dramatically improving glutathione, and normalizing platelet levels (a marker of inflammation)

Importantly however, RSL3-containing combinations displayed growth control even after drug washout, with the triple combination being most effective and independent of the pre-treatment regime, consistent with having a cell lethal effect (Fig

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Anemia develops in normal mice tranplanted with mk bone marrow, indicating that mk erythroid precursor cells also have a defect in red cell iron uptake