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[13] [14] Concentration and state in cells [edit] In rat liver, the total amount of NAD + and NADH is approximately 1 mole per gram of wet weight, about 10 times the concentration of NADP + and NADPH in the same cells

In addition to benefits ranging from heavy metal chelation, antioxidant and anti-inflammatory actions, they also activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2), an antioxidant response element signalling pathway

These findings suggest that FSP-1 could be a promising anti-tumour target, given its tumour-promoting roles in both CAFs and cancer cells

DHODH, a mitochondrial inner membrane enzyme, catalyzes the oxidation of dihydroorotate (DHO) to orotate while transferring electrons to CoQ10, thereby generating CoQ10H 2 that scavenges ROS and phospholipid hydroperoxides (PL-OOHs) within mitochondria and prevents ferroptosis (Mao et al., 2021