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FOXO4-p53 protein-protein interaction inhibitor Sequence: LTLRKEPASEIAQSILEAYSQNGWANRRSGGKRP all D-amino acids in retro-inverso configuration (34 residues) Origin: Developed by Peter de Keizer and colleagues at Erasmus University Medical Center (Rotterdam)

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CSC in HNSCC were inhibited with PF-2341066 (a c-MET inhibitor) and -Catenin was shown to be the downregulating factor contributing to CSC elimination [92]