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Active skin infection, open lesions, dermatitis, complex wound history, pregnancy, lactation, immune compromise, copper metabolism disorders, and extensive concurrent dermatologic therapy may require added clinician evaluation

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It has been shown in a recently published study that long-term exposure to high concentrations of iodine in drinking water, i.e., above 300 g/L in non-pregnant adults and above 450 g/L in pregnant and lactating women, was associated with an increased risk of abnormal blood pressure and abnormal blood glucose concentration, mainly in the latter group of individuals [202]

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