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In vivo testing in xenograft mouse models confirmed that UCM 1037 suppressed DX3 tumor growth and demonstrated greater inhibitory activity compared to melatonin alone at the same dose (16 mg/kg) [87]

10.1007/s00213-014-3687-y Psychopharmacology (Berl)

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A clinical study has shown an association between increased oxidative stress and renal proximal tubular cell injury in CKD patients with proteinuria ( Effects of the Active Ingredients From Chinese Yang/Qi-Invigorating Botanical Drugs on Mitochondrial Function and Chronic Kidney Disease To elucidate mechanisms of action, it is essential to identify the chemical components responsible for the pharmacological action(s) of Chinese Yang/Qi-invigorating tonic botanical drugs