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Monitoring Response Patients or research participants typically notice: Appetite suppression within the first 12 weeks Early satiety and slower gastric emptying by weeks 34 Weight loss trends becoming evident by week 8 Continued improvements in glucose metabolism when paired with semaglutide or tirzepatide Side Effects and Considerations Common side effects include: Nausea Mild gastrointestinal discomfort Constipation Injection site reactions These effects are generally transient and dose-dependent, which is why titration is important

The original Russian protocols use daily dosing during courses

However, it's essential to follow recommended dosages and consult with a healthcare professional if you have specific health concerns

Second, PPI treatment promotes the occurrence of CDAD, which is a common cause of IBD (Sokol et al., 2008)