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Monti and colleagues in Uruguay ran a double-blind crossover of 25 nmol/kg over four nights and found that although several sleep measures moved in the expected direction, none differed significantly from baseline or placebo, and where differences did reach significance for NREM and stage 2 sleep, the same differences already existed at baseline

The issue is the delivery problem: the IBD studies used nanoparticle-encapsulated oral KPV, not bare peptide

suggest that the anti-inflammatory mechanisms induced by TREM2 may be associated with the PI3K-Akt-FoxO3a axis

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