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Healthy subjects in this phase 1 study who were given a 225 mg dose had a mean concentration of 22.1 g/mL at day 29 and those given 675 mg had a mean concentration of 24.1 g/mL at day 85

These characteristics support reproducible data collection and dependable performance across controlled laboratory models

Nevertheless, studies utilizing more specific biomarkers of vitamin B 12 status, including measures of holo-transcobalamin and methylmalonic acid, have shown more consistent results and a trend towards associations between poor vitamin B 12 status and faster cognitive decline and increased risk of Alzheimers disease (82-86)

Biggs SN, Halliday J, Hammarberg K