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7) Off-label : Treatment of & dissecting aortic aneurysm To produce controlled hypotension in neurosurgery to reduce bleeding in the operative field, and in patients undergoing electroconvulsive therapy Low dose mecamylamine may be of potential use in blocking the physiological effects of nicotine in patients under treatment for smoking cessation, as well as several other neuropsychiatric disorders (Shytle et al, 2002

Acknowledgements Figures 1, 2, 3 and 4 in this review were created using BioRender.com ( Funding This work was supported by the National Natural Science Foundation of China [grant numbers 81973498 and 81774283], National Science Foundation For Distinguished Young Scholars [grant numbers 82125037], the Joint Open Project of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica and Yangtze River Pharmaceutical Group (No