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Family aggregation related to lung cancer is likely multifactorial, including exposure to secondhand smoke, major genetic factors (e.g., chromosome 6p locus, CYP1A1 gene), other genes that modify risk of lung cancer, and genes that may enhance nicotine addiction or modify nicotine metabolism (DAmico, 2008

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They are often confused with psychotropic substances, which alter our state of consciousness, perception of the world, perception and functioning of the senses