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Lin S, Cheng H, Yang G, Wang C, Leung CK, Zhang S, et al

All metrics show improvement in Figure 3G , with average gains ranging from 6%-20%

Another study in rats on the same HFD plus 0.25 g LA/100 g body weight demonstrated that SIRT1 and SIRT3 enhanced LA's antioxidant defense by deacetylating Foxo3a and PGC1, thereby reducing oxidative damage of mitochondrial DNA, restoring oxidative balance, and resisting oxidative stress