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These cytokines play a role in the regulation of cellular and subcellular communication and maintain equilibrium with other anti-inflammatory cytokines, including IL-10, IL-4, IL-13, and TGF-, reducing their potential harm [32, 33]

In human plasma, UA metabolizes to around 55% in about 5 min after production

Table 11.6 Dietary Reference Intakes for Selenium Selenium at doses several thousand times the RDA can cause acute toxicity, and when ingested in gram quantities can be fatal

In -synuclein-induced PD mouse model, Zhang and collaborators showed that the administration of caffeic acid prevents the neurodegeneration of dopaminergic neurons in SN and improves behavioral abnormalities by stimulating autophagy through the JNK/BcL2 pathway (Zhang et al., 2019)