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The TRIUMPH-4 data confirm that retatrutide achieves greater peak weight loss, but CagriSema's nearer-term availability and established semaglutide safety record may make it the first to reach patients

583 In addition to the traditionally recognized loss of dopaminergic neurons in the substantia nigra and intracellular alpha-synuclein (-syn) deposition, the brains of PD patients exhibit iron deposition, heightened oxidative stress, and lipid peroxidation damage

[ 9 , 10 ] These conflicting results highlight the uncertainty that persists in this area of research