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A human RCT from Wuhan, China, showed that ALA therapy (1200 mg/d) for 7 days, could reduce a 30-day all-cause mortality rate (37.5%) in critical COVID-19 patients 535

To seek in vivo correlation, the authors assayed total glutathione in lungs and livers from MK2 (homozygous knockout) mice

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indicated that GPX4 and GSH levels were decreased, and cellular iron and MDA levels were increased in a mouse model of myocardial ischemiareperfusion (MIR, ischemia 30 min and reperfusion 24 h) injury [90]