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No systematic adverse-event data from controlled trials Regulatory note / FDA warned against compounding pharmacies marketing BPC-157 in 2023 and 2024 What Is BPC-157 and Why Is It Used Off-Label for GI Healing

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Phase 2 data reported roughly 10-11% weight loss versus placebo at ~26 weeks as a monotherapy example, and Phase 3 CagriSema data reported substantially larger reductions when combined with semaglutide

Thus, among participants without a current diagnosis of MDD we excluded those with a diagnosis of anxiety disorder (n = 508) and dysthymia or minor depression (n = 66)