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A larger population-based pharmacokinetic analysis including data from Phase II and Phase III clinical trials in patients with atrial fibrillation suggests that apixaban clearance may be 15% lower in Japanese patients compared to the overall population, which would correspond to an 18% higher exposure

Abbreviations BBB: Bloodbrain barrier CNS: Central nervous system FMO: Frontier molecular orbital GPx4: Glutathione peroxidase 4 MD: Molecular dynamic MM/GBSA: Molecular mechanics with generalized Born and surface area solvation MolSA: Molecular surface area MS: Multiple sclerosis PSA: Polar surface area QSAR: Quantitative structureactivity relationship rGyr: Radius of gyration RMS: Root mean squared RMSD: Root mean square deviation RMSF: Root mean square fluctuation SASA: Solvent accessible surface area References B.K.T

Lewis has 20 years of experience practicing nutritional and holistic medicine