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In some embodiments, a pulsed release profile is achieved by solubilizing up to 40% of the delivered dose of the therapeutic agent (e.g., micronized therapeutic agent, or free base or salt or prodrug thereof

Additionally, patients should be observed for signs and symptoms of megaloblastic anemia, such as fatigue, pallor, and anorexia

Depletion Over Time: The body uses Vitamin B12 continuously for vital functions, and its levels can deplete over time

Clinical trials have used doses of 25-30 nmol/kg by IV infusion (Schneider-Helmert et al., 1981Subcutaneous administration and oral intestinal absorption have also been studied