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In humans, the highest concentration of glutathione is found in the liver, where it is used as an anti-toxin to inactivate drugs, hormones, and foreign chemicals

Its involvement is well established in endocrine disorders, autoimmune conditions such as rheumatoid arthritis, gout, inflammatory bowel disease, and in hypersensitivity reactions such as anaphylaxis, as well as in environmentally induced diseases that follow asbestos exposure or smoke inhalation

Short term successful trials were followed by studying the combination of finasteride and doxazosin for a period of 4.5 years as Medical therapy for Prostate Symptoms

Oxidative stress was assessed by the quantification of protein carbonyls and MDA using Protein Carbonyl Colorimetric and TBARS Assay Kits, respectively (Cayman Chemical, Ann Arbor, MI)