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The evolution of DDSs from passive carriers to intelligent, patient-centric platforms signifies promising progress in gout and hyperuricemia management, yet substantial challenges in clinical validation, scalability, and long-term safety persist, underscoring the need for sustained interdisciplinary efforts to fully realize their therapeutic potential

Quantitative and digital PCR Quantitative PCR was performed on purified genomic DNA using TaqMan Advanced Master Mix (Applied Biosystems), 250 nM primers and 333 nM probes (sequences listed in Supplementary Dataset 1), and a QuantStudio6 (Applied Biosystems)

Secondarily, there may be: -Burning or Stinging on the face

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