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Previous studies have shown that nicotine can cause brain damage when brains are still growing

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In TNF - -stimulated human keratinocytes, the expression levels of SIRT1 , SIRT2 , SIRT3 , SIRT4 and SIRT5 are downregulated, while those of SIRT6 and SIRT7 are upregulated, indicating a necessary function of SIRTs in inflammation [143]

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