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However, the prospective Shanghai Osteoarthritis Cohort study showed that GLP-1RA users with KOA and diabetes exhibited a greater reduction in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total and pain score and a lower occurrence of knee surgery compared to controls

This significant discrepancy between physiological requirements and therapeutic doses highlights the need for a deeper understanding of B12 absorption dynamics, rather than focusing solely on intake quantity

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