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This means that in rats with bile duct ligation, the therapy reversed the stasis peripherally (note also the counteracted arrhythmias) and centrally, and re-established blood flow and largely rescued rats with ligated bile duct at its entry into the duodenum, thereby counteracting the intracranial (superior sagittal sinus) hypertension, portal and caval hypertension and aortal hypotension [11,12,13,14,15,16,20,22,23,24,25]