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Free Radic Res 39:573580 Clark DD, Sokoloff L (1999) Circulation and energy metabolism of the brain

The selection of the starting dose involves balancing the need to minimise toxicity risk to the participant, while ensuring the induction of pharmacologic activity in subsequent studies

Metabolic Disorders Obesity and Insulin Resistance: Dysregulated PC metabolism contributes to obesity-related insulin resistance by impairing insulin signaling pathways

Polymeric nanoparticles, like those composed of PLGA or chitosan, provide regulated drug release and safeguard against enzymatic degradation, while improving skin penetration due to their adjustable size, surface charge, and hydrophobicity [296]