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Efficacy and safety of trastuzumab Deruxtecan in patients with HER2-Expressing solid tumors: primary results from the DESTINY-PanTumor02 phase II trial

Using cellular models (liver cancer-derived), the study showed that vorinostat reduces HIF-1 protein levels under hypoxic conditions, leading to impaired hypoxia-responsive gene expression (203)

Lowry, E

Therefore, disruptions in these detoxification pathways can lead to the accumulation of harmful intermediates, potentially contributing to a range of health disorders, including liver diseases, hormonal imbalances, and increased susceptibility to chronic illnesses (14)