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If left untreated for a prolonged period of time, severe acid reflux can develop into precancerous lesions or esophageal cancer

and in 2005, Needham, Mass., became the first and until New York passed its regulation last week the only municipality to approve a "21 law." Needham has reported that since 2005, it has seen a drop of more than 50 percent in its youth smoking rate

Most likely, the developmental risks are the same as smoking cannabis, but this topic is understudied as most studies use inhaled cannabis

Front Sustain Food Syst 4:561820 Acknowledgements The authors acknowledge the respected reviewers for their suggestions for the improvement of the manuscript